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All ELISA experiments were repeated in technical duplicates with apical supernatants collected from the AX12 Lung-on-chip

Smokers have a 44% higher risk of developing cancer than never smokers, and are twice as likely to die from cancer as never smokers

By binding to the brains nicotinergic receptors, varenicline both facilitates a reduction in the severity of nicotine withdrawal symptoms (such as craving and moodiness) and prevents nicotine from releasing the pleasure-inducing acetylcholine upon smoking

These additives alter the natural flavor of tobacco and offer a more pleasurable experience to consumers