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Continuously elevated Noradrenaline and dopamine responses can be impacted by nicotine levels, which may contribute to the ADHD [74] that accompanied by developmental psychopathology [74] A number of compelling rodent studies demonstrate that embryonic nicotine exposure causes changes in the DA and NE systems, which are all connected to Impulsive, agitated, and careless behavior [54] Once again, the data shows that risk levels differ by gender, with men being more susceptible to alterations in forebrain catecholamines [66]

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In the 1960s, dogs and other animals were used in such experiments

doi: 10.1016/j.bbrc.2004.11.033 46 HoffmannD.WynderE