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Two key genetic factors are: APOE (Apolipoprotein E) : Variants of this gene, like APOE4 , are linked to higher LDL-cholesterol levels and a greater risk of heart disease, while APOE2 may be associated with lower LDL-cholesterol

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To assess the most significant among these, this paper follows the guidelines of Fowles and Dybing ( 6 ), who suggested identifying chemical components with the greatest potential for toxic effects, specifically those associated with cancer, respiratory, and cardiovascular diseases