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13 A company seeking to market an ENDS as an actual smoking cessation tool (i.e., with smoking cessation claims) such as the nicotine gum or patch would need FDA premarket approval as a drug, because smoking cessation claims trigger the first prong of the drug or device definition, described above

When these systems are taxed or imbalanced, symptoms such as insomnia, anger, depression, or restlessness may occur

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People who disliked smoking formed the first anti-tobacco group in the country named the Deutscher Tabakgegnerverein zum Schutze der Nichtraucher (German Tobacco Opponents' Association for the Protection of Non-smokers)