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These effects were that nicotine and other parts of cigarette smoke are known to affect gut motility, the guts sensitivity to pain, intestinal permeability (the ability to let liquids or gasses pass through it), immune signalling, and the gutbrain axis (more on that below)

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Breit S, Kupferberg A, Rogler G, Hasler G (2018) Vagus Nerve as Modulator of the Brain-Gut Axis in Psychiatric and Inflammatory Disorders

Great Basin Anthropol

It also climbed in rural areas from 4.20 per cent in 2011-12 to 7.55 per cent in 2022-23

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