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Valproic Acid Combo Therapy Fails to Improve Survival of SMA Type I Infants, Clinical Trial Shows Written by | Valproic acid (VPA) combined with L-carnitine previously suggested as a potential therapy for infants with spinal muscular atrophy (SMA) does not improve the survival of SMA type I patients, according to the results of the CARNIVAL clinical trial

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La Camera G, Gelsomino L, Malivindi R, et al

The intervention duration was 2 weeks in one trial (Reference Revuelta-Iniesta and Al-Dujaili39) , 4 weeks in three trials (Reference Ahmed Al-Naggar, Osman and Abdulghani23,Reference Lecoultre, Carrel and Egli32,Reference Mortazavi, Paknahad and Hasanzadeh34) , 8 weeks in nine trials (Reference Basu, Betts and Mulugeta26,Reference Cardoso, Salgado and Cesar28,Reference Hochkogler, Schweiger and Rust29,Reference Martnez-Lpez, Sarri and Mateos33Reference Mousavi, Vafa and Neyestani35,Reference Superko, Bortz and Williams40,Reference Vieira Senger, Schwanke and Gomes43,Reference Wedick, Brennan and Sun44) , 12 weeks in four trials (Reference Bak and Grobbee25,Reference Kajimoto, Kajimoto and Yabune30,Reference Kobayashi, Kawano and Ukawa31,Reference Nabi, Sedighinejad and Haghighi37) and longer than 12 weeks in the other five trials (Reference Alperet, Rebello and Khoo24,Reference Bhn, Croft and Burrows27,Reference Ohnaka, Ikeda and Maki38,Reference Toolsee, Aruoma and Gunness41,Reference van Dusseldorp, Katan and van Vliet42)

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2 Furthermore, quantitative studies of these biomarkers have demonstrated that some may discriminate mild self-limiting forms of COVID-19 from severe progressive forms of the disease