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In addition to self-reported smoking status and CO measures taken at each visit, urinary anabasine and anatabine concentration will be used as the principle objective measure of the primary outcome (continuous abstinence from smoking during the last 4 weeks of treatment)

The above-noted reports provided evidence of reduced levels of HPHCs in e-cigarette aerosols compared to cigarette smoke, others have raised concerns about the levels of carbonyl compounds such as acetaldehyde, acrolein, and formaldehyde in aerosols generated by heating e-liquids, as well as metals that may be released from the device components [8, 54, 55]

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Sources MHRA / GOV.UK - E-cigarette regulations for consumer products

That would be weird. Its a clairvoyant, appropriately enough, who gives the first hint that something will go wrong on the second day