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just the inner element is frozen into the outer sleeve

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Unlike e-cigarettes, which use nicotine-laced liquid, heat-not-burn products use real tobacco

Environmental impact: Both products pose ecological challenges, such as waste and emissions, though vaping typically has a smaller carbon footprint than heated tobacco

Furthermore, the authors proposed a mechanism-of-action, whereby 2 -agonists stimulate adenylyl cyclase, leading to cyclic AMP accumulation, activation of protein kinase G, and opening of large conductance calcium-activated potassium (BK Ca ) channels, thereby inhibiting sensory nerve depolarisation