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As the smoke escapes, drifting up from your bottom lip, inhale gently from your nose

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In contrast, it has been shown that cigarette smoke extract (CSE) contains lipophilic components, such as aldehydes and polycyclic aromatic hydrocarbons, that reduce mitochondrial membrane potential and ATP levels [4]

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A recent systematic review with meta-analysis compared the health effects of e-cigarettes, traditional cigarettes and combined use of both, showing associations between e-cigarette use and several diseases, including increased cardiovascular risk

their cited source is: CDC (Centers for Disease Control) The Health Consequences of Smoking: A Report of the Surgeon General