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Users may quickly develop a tolerance, requiring larger doses to achieve the same high, further increasing the chance of toxic overdose and other life-threatening consequences

The impact of surgical-site infections following orthopedic surgery at a community hospital and a university hospital: adverse quality of life, excess length of stay, and extra cost

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And among current smokers, the earlier the study participants started, the higher their likelihood of dying during the follow-up period

Centers for Disease Control and Prevention (2001)

With caffeine being filtered more quickly through the body, this may lead to increased caffeine consumption amongst smokers in order to maintain the stimulating effects offered by coffee