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[58] With constant use of nicotine, tolerance occurs at least partially as a result of the development of new nicotinic acetylcholine receptors in the brain

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Both companies say industrywide volume actually fell marginally during the first nine months of the year

Buying in larger quantities helps reduce the overall cost per pack

The Health Consequences of Involuntary Exposure to Tobacco Smoke: a Report of the Surgeon General (Centers for Disease Control and Prevention, 2006)