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Beyond confirming an association between smoking and depression, our study demonstrates dose-dependent effects of smoking heaviness on depression severity, while longer time since cessation predicted both reduced symptoms and longer periods of remission

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Hwang K, Walters RC, Lipshultz LI

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Research suggests that people who smoke during detox experience higher withdrawal symptoms and cravings compared to non-smokers, thus reinforcing the connection between smoking and increased relapse risks