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Compared with another study based on the UK Biobank [37], the current PRS contains fewer highly independent SNPs in each locus to avoid overinflation of the GWAS summary results caused by many linkage disequilibrium SNPs

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There are defenders of the scheme out there who claim it is merely a question of getting used to a different pattern, but in reality it is a painfully counter-intuitive pattern: when ones brain perceives four seemingly equivalent symbols on the keyboard (up, down, right, left arrows), it wants to interpret them as having equivalent functions having to remember that two of them move you forward or backward from place to place, while the other two spin you around on the spot, requires constant brain activity which, hum hum, could probably be spent on something more intellectually and emotionally rewarding than a pat on the back from Tim Schafer and an extra achievement in your Steam library