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And Manns prescription is simple and finally reassuring: I believe artists should suffer. The point of which, as father frequently intones to son in the Calvin and Hobbes strips, is to build character

But if you smoke cigarettes, does your risk increase

In recent years, data have emerged showing that nicotine is transformed into some cancer-causing metabolites during its destruction in the body

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Acknowledgements The authors acknowledge support from the laboratories of Kathleen Caron, Margeaux Marbrey, Claire Doerschuk, and Susan Murphy and from Carolyn Suitt and the CGIBD Histology Core at the University of North Carolina