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Abbreviations CASP: Critical Appraisal Skills Programme CI: Confidence Intervals HR: Hazard Ratios ICD: International Classification of Diseases NIH: National Institutes of Health OR: Odds Ratio PRISMA: Preferred Reporting for Systematic Review and Meta-analysis RR: Risk Ratios SLT: Smokeless tobacco References Hecht SS (2019) Smokeless tobacco and its constituents

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The Breaking Point: Clinical Consequences When you subject your cardiovascular machinery to years of chronic inflammation, elevated blood pressure, and stiffened arteries, the clinical outcomes are brutal and entirely predictable

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