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Linus Pauling Institute Oregon State University Reviewed in July 2024 by: Mary Ellen Sanders, Ph.D

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In conclusion, whatever medication that increases endogenous portal insulin (signaling) in T2DM patients, regardless of the glucose level (specifically sulfonylurea derivatives and peroxisome proliferatoractivated receptor [PPAR-] agonists, but not dipeptidyl peptidase-4 inhibitor [DPP4i], or glucagonlike peptide-1 [GLP-1] analogues) will lead to an increase in body weight, even when caloric intake is not increased

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The largest and longest trial, Nathan I 178 , a multicentre, randomized, double-blind, parallel-group trial, evaluated the efficacy and safety of 600 mg -lipoic acid over 4 years in patients with mild-to-moderate diabetic neuropathy