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However, the lack of effect on total nicotine exposure indicates VLNC noncompliance, suggesting that smokers with SMI may respond to a reduced-nicotine standard by substituting alternative forms of nicotine." "Additional doseresponse relationships have been detected on the number of cigarettes smoked per day when low and high nicotine Spectrum cigarettes are available

It was important to conduct the research because e-cigarettes have gained popularity as a less harmful alternative to conventional cigarette smoking, but it remains unclear if switching to e-cigarette use after conventional smoking cessation affects future lung cancer risk, Dr

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