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6 While the role of conventional cigarette smoking in oral cancer development is well-known, the role of ENDS in oral cancer and systemic disease is less clear

Macrophages regulate epithelial and stromal cell function by secreting enzymes and inflammatory factors that act directly and indirectly on airway structural cells, such as IL-1, TNF-, IL-8, monocyte chemoattractant protein-1(MCP-1), reactive oxygen species (ROS) and MMPs, directly involved in the process of airway remodelling 60,61

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Although relatively new, HTP have been steadily increasing in popularity across the globe

Roosaar A, Johansson AL, Sandborgh-Englund G, Axell T, Nyren O

These are known as pod or tank style e-cigarettes