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Nicotine (absorbed into the blood through the vapour produced by the ENDS) is likely to only enter the brain between 5 and 20 seconds after each inhalation 11 , and modelling this effect within a conventional fMRI design would be difficult, since the timing of the nicotine hit after each trial is somewhat uncertain

Authors' contributions CH performed the statistical analysis and wrote the first draft of the manuscript

Understanding the difference between the two can help smokers choose the right tobacco for their preferred style of smoking

He was a businessman and to see such a strong man deteriorate like that, it was horrendous

However, future archaeologists will likely find cigarette butts and vaping devices and will use documentary sources to discuss the history of tobacco use during the 21st century.

Cerhan, J