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In subgroup analysis, the effect of drugs on overall success was assessed via a logistic regression model adjusted for polymorphism (bupropion-favorable polymorphism, varenicline-favorable polymorphism), sex, age, baseline carbon monoxide concentration, baseline heart rate, depression, anxiety, antidepressants/anxiolytics use, Fagerstrm test, Issa score, concomitant medications, chronic obstructive pulmonary disease, diabetes mellitus, systemic arterial hypertension, other diseases, and adverse events, taking the population on bupropion monotherapy as reference

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While these data provide useful physiological context, their applicability to adolescents should be interpreted with caution due to developmental differences in lung maturation and exercise capacity