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Zavodnick AD, Ali R

Am J Clin Nutr 2011;93:172-85

In muscle tissue, IGF-1 LR3 is instrumental in increasing the DNA and RNA synthesis, which are crucial for protein synthesis and muscle cell proliferation, leading to hyperplasia (increase in the number of muscle cells) and hypertrophy (enlargement of existing muscle cells)

The health promoting characteristics contributed by lactic acid bacteria in kefirs from different geographical locations such as Brazil, Ireland, Malaysia, Iran, Australia and Argentina have been investigated extensively and well-documented with the approach of Next Generation Sequencing, an advance metagenomic technique that allows comprehensive taxonomic identification and profiling (presented in Tables 2 and 3)

It is the same cascade native IGF-1 and insulin partially share, which is why IGF-1 LR3 is frequently used as a research tool for studying mTOR-dependent cellular processes under sustained receptor activation