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Ernst Wynders landmark studies date as far back as 1950, and described tobacco smoking as a possible factor in lung cancer

doi: 10.1002/acr.22282 Summary Keywords systemic lupus erythematosus, lifestyle, diet, smoking, alcohol, ultraviolet radiation Citation Chen J, Liao S, Pang W, Guo F, Yang L, Liu H and Pan Q (2022) Life factors acting on systemic lupus erythematosus

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The combination treatment was also well tolerated by most participants and did not produce any severe side effects