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Statistically significant increases in MS risk were identified for males who were active smokers after age 19, with an increased risk of about 59%, and for females who were not active smokers after age 19, with a roughly 43% higher risk

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Moreover, RNO reduced mesenchymal markers while increasing epithelial markers in primary human bronchial epithelial cells isolated from smokers and COPD patients small bronchi

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The study found contradictory results regarding its effect on blood clotting, with data suggesting that it could increase blood clots and decrease them