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In the third step, we extracted age group-specific RR data and relevant bias covariates from the studies identified in our systematic review approach of age-specific smoking risk on CVD outcomes, and used MR-BRT to model the age pattern of excess risk (that is, RR-1) of smoking on CVD outcomes with age group-specific excess RR data for all CVD outcomes

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Its likely due to a number of social factorsincluding quality of health care received, late diagnoses, apathetic health care providers, medical racism, and differential smoking behaviors