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While about half of nicotine-free electronic cigarette users from this cohort were able to quit the following year, it is important to note that from 2017 to 2019, about 15% of users each year transitioned from nicotine-free to nicotine-containing electronic cigarettes (88)

However, little is known about how CS-induced EVs regulate the pathophysiological processes of OLK, even though the oral mucosa is the first-line site affected by CS

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Long-Term Cravings Long-term studies have shown that cravings can persist for months

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