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The Mathematics of Switching to Discount: Some decisions warrant deep reflection and consideration

Grading of recommendations Recommendations are graded according to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system.21 Whether a recommendation is strong or conditional will depend on considerations such as certainty in estimated effects of an intervention, including magnitude, as well as estimates of how patients value and prioritize outcomes, variability of these estimates, and wise use of resources

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However, it emphasized the need for further investigation into the risks of cardiac arrest and tachyarrhythmias, especially in patients with existing heart conditions and in females

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