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Exposure ranged from 1 pack-year to 100 pack-years, with the 85th percentile of exposure in the exposed group being 49.75 pack-years

Efforts to inundate young people with e-cigarette content on social media continue today: Influencers on Instagram frequently posted branded vaping content that promoted specific brands, failed to disclose brand relationships, rarely included warning labels about the addictiveness of nicotine, and featured youth-appealing cartoon imagery, violating both federal and platform regulations

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Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines 31 for each of our systematic reviews, we identified studies reporting relative risk (RR) of incidence or mortality from each of the 36 selected outcomes for smokers compared with nonsmokers

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PR = 2.12 [1.932.41] for 45-year-olds and PR = 1.72 [1.502.05] for 65-year-olds), meaning the inverse age gradient in non-daily smoking became more pronounced over time (e.g