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In vitro and preclinical studies examine its influence on NAD salvage pathways, energy expenditure mechanisms, and adiposity regulation under controlled experimental conditions

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Outcomes Co-primary endpoints were percentage change in body weight from baseline to week 104 and achievement of weight loss of at least 5% of baseline weight at week 104

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Low Dose Naltrexone is a pharmacologically active opioid antagonist, conventionally used at higher doses for opioid addiction and alcohol dependence

All patients had failed CSAI owing to lack of efficacy, poor tolerance, contraindications or refusal