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In addition to being a known cause of cancer, cadmium can lead to kidney failure, brittle and painful bones and chronic breathing issues such as bronchitis and asthma

Unlike the nuclear genome, mitochondrial genomes lack histones, therefore, rather than histone-related modifications, research on mitochondrial gene expression regulation focused on mtDNA methylation and has demonstrated its differences in aging [35, 36] and various diseases including metabolic disorders [37, 38], neurodegeneration [39], and cardiovascular diseases [36, 40]

Australia was the first country in the world to introduce plain packaging legislation in December 2011, fully implementing it in December 2012 - the Tobacco Plain Packaging Act 2011 and the Tobacco Plain Packaging Regulations 2011