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The LPS groups were included for 2 purposes: first, to serve as a positive control to demonstrate osteoclast activation [25] and concurrent inhibition of osteoblast differentiation [26]

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Finally, there are countries (Canada, Austria, UK, US, Netherlands, Australia) where the decline is caused by an approximately equal contribution to each side of the e 50 85 gap (Additional file 1: Figure S5)

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