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Page last updated: February 4, 2026

Blockages in blood vessels can sometimes result from substances other than blood clots, such as: Fat from the marrow of a broken long bone Collagen or other tissue Part of a tumor Air bubbles Anyone can develop blood clots that lead to acute pulmonary embolism, but certain factors can increase the risk, such as: Family medical history of blood clots or pulmonary embolism Heart disease, especially heart failure Inherited disorders that make the blood more likely to clot Certain cancers, especially pancreatic, ovarian, and lung cancer, or cancers that have spread (metastatic cancer) Surgery, especially bone, brain, or joint surgery Long-term immobility such as bed rest or inactivity during long plane or car trips Smoking Excess weight or obesity Pregnancy Birth control pills or estrogen therapy Symptoms of Acute Pulmonary Embolism Symptoms of an acute pulmonary embolism vary depending on the size of the blood clots, the amount of the lung tissue affected, and whether the patient also has heart or lung disease

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The tobacco industry should pay for the damage caused and be held to account for the environmental impact of its products all the way through the supply chain. Join our commenting forum Join thought-provoking conversations, follow other Independent readers and see their replies Comments

A flannel petticoat will wear as nearly as long again, if turned hind part before, when the front begins to wear thin