Propargyl-Acetyl-Val-Cit-PAB(m-PEG8)-PNP Size:10mg NRX-2663 acts as molecular glue

NRX-2663 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome

British Journal of Pharmacology n/a

Product Name Thalidomide-O-C4-azide Synonyms Thalidomide-4'-O-C4-azide CAS Number n/a Related CAS Molecular Formula C17H17N5O5 Molecular Weight 371

Product Name Thalidomide-5'-C3-PEG1-OH Synonyms CAS Number n/a Related CAS Molecular Formula C18H20N2O6 Molecular Weight 360

NCCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Propargyl-Acetyl-Val-Cit-PAB(m-PEG8)-PNP Size:10mg NRX-2663 acts as molecular glueSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload to the linker. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine