Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:100mg ACS Chemical Biology 2020

ACS Chemical Biology 2020

S)-AHPC-CO-PEG3-C2-acid Synonyms CAS Number 2140807-42-5 Related CAS Molecular Formula C32H46N4O9S Molecular Weight 662

602 SMILES OCCOCCOCCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

HQ461-mediated degradation of cyclin K impairs CDK12 function

resulting in cytochrome c release and caspase-dependent cell death

Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:100mg ACS Chemical Biology 2020SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase