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Summary: pro-oxidative effects of vitamin C require intravenous dosing

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Zhao IS, Mei ML, Burrow MF, Lo ECM, Chu CH

Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism

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These findings are applicable to clinical pain management with acetaminophen, but the analgesic mechanism of acetaminophen has not been elucidated completely