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The redox status has been suggested to regulate stem cell self-renewal and differentiation, and accumulating evidence indicates that stem cells undergo self-renewal in the environment with low ROS levels, while ROS levels increase in differentiated stem cells [117, 118]

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Rev Neurosci 27(6):651668 Shin J-H et al (2011) PARIS (ZNF746) repression of PGC-1 contributes to neurodegeneration in Parkinsons disease

Once in the cytoplasm, it binds and stabilizes KEAP1, thus interfering with NRF2 stabilization

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Pinto, A