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A deficiency in iron, vitamin B12 or B6, or folate, or the bodys inability to assimilate or use a certain nutrient, can contribute to anemia

Editor information Editors and Affiliations Rights and permissions Copyright information 2025 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Zaro, J.L., Wang, J., Shen, WC

During ER stress, stimulator of interferon genes (STING), a transmembrane protein predominantly located in the ER, responds to stress signals and promotes inflammasome activation, such as NLRP3, via the STING/ TANK-binding kinase 1 (TBK1) pathway, leading to tissue inflammation (61)

A few studies have also used metformin, which, by and large, showed normalisation of ALT levels ( Reference Duseja, Das and Das 74 , Reference Duseja, Murlidharan and Bhansali 76 ) even when lifestyle modifications did not have much of an effect ( Reference Duseja, Das and Dhiman 77 )

Other risk factors include pernicious anemia, neurological symptoms, and a history of weight loss surgery

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