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PE-22-28: PE-22-28 is a synthetic 7-amino acid peptide derived from spadin that selectively blocks TREK-1 two-pore domain potassium channels with an IC50 of 0.12 nM

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Conclusions To our knowledge, this is the first human study: (a) to investigate the co-administration of GR from BSE and mustard seed powder with known Myr activity, (b) to include a standardized dose of ascorbic acid (Vit C), a known cofactor to the Myr enzyme, (c) to evaluate the possibility of predicting gut microbial responsiveness to GR, and (d) to investigate the effects of a well-defined source of Myr on conversion of broccoli seed GR to SF and its ability to modulate gut bacteria

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57 Van EschA.Van Steensel-MollH

Only a head-to-head randomized controlled trial could definitively establish superiority, and that trial has not been conducted