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C., Barajas, R

These data support a normal role for insulin signaling, as a determinant of chondrocyte size, which is apparently cannot compensated by local upregulation of IGF-1/IGF-1R

When consumed as a standard powder or tablet, the fragile tripeptide structure is rapidly degraded by gastric enzymes (such as gamma-glutamyltransferase) and undergoes aggressive first-pass hepatic metabolism, reducing the amount of GSH in the blood [2]

Protein Databank identifier 4INS)

Soy isoflavone-specific biotransformation product S-equol in the colon: physiological functions, transformation mechanisms, and metabolic regulatory pathways