Alcohol oxidative metabolism induces several events that are involved in ARLD progression, including the disruption in the balance between fat synthesis and degradation that underlies the onset of steatosis and the alterations in mitochondrial function and morphology
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Front Endocrinol (Lausanne) 4:102
Specifically, superoxide anion and hydroxyl radicals, also known as free radicals, are strongly oxidative due to the existence of one or more unpaired free electrons in their outer electron orbitals, therefore easily grabbing electrons from other substances and predisposing to free radical chain reactions, which causes immense damage to DNA, proteins, and lipids ( ROS production has been unravelled to play a critical role in the pathogenesis of RA by directly or indirectly inducing the participation of relevant cells in the pathogenesis of RA ( 2 -, inhibit the synthesis of matrix components such as proteoglycans by chondrocytes and damage the extracellular matrix through activation and up-regulation of matrix metalloproteinases, leading to cartilage damage ( 3.3 Abnormal energy metabolism Cells in living organisms acquire energy from sugars, as do chondrocytes, which obtain energy through two major metabolic pathways, namely glycolysis and the Krebs cycle
Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis
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