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10.1186/s12951-021-01058-1 449 YeK.ChenZ.XuY

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Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3-Diindolylmethane: Anti-Oxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy

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Although we failed to detect robust SARS-CoV-2 replication within human monocytes by using this method ( Supplementary Figure 4 ), SARS-CoV-2 exposure to monocytes was sufficient to induce IL-1 secretion at MOI of 1, which was not seen in cultures incubated with HI-CoV-2 at the same MOI or with SARS-CoV-2 media only ( Figure 6A )

106 As a result, higher doses are often required to achieve therapeutic efficacy, which may increase the risk of adverse effects