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10.1203/00006450-198506000-198506008 Pediatr

The glutathione-deficient, cadmium-sensitive mutant, cad2-1, of Arabidopsis thaliana is deficient in gamma-glutamylcysteine synthetase

In addition, some proteins can stimulate tumor cells to switch from oxidative phosphorylation (OXPHOS) to glycolysis, in turn leading to lower levels of GSH, which suppress the activity of GPX4 and boost the accumulation of lipids, thus resulting in ferroptosis [21,22,23,24]

That means its approval status, access routes, labeling, and routine clinical use may differ from medicines that already have formal regulatory approval

In a state of mitochondrial dysfunction, partially metabolized fatty acids can build up inside the mitochondria, forming toxic acyl-CoA compounds that inhibit essential enzymes and cause severe oxidative stress

282 Fatty liver disease Fatty liver disease can be classified into alcoholic and nonalcoholic fatty liver disease (NAFLD)