Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan fluorescent Ubiquitination and degradation of SUMO1

Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

Product Name DOTA-tris(t-Bu)ester-C4-azide Synonyms CAS Number n/a Related CAS Molecular Formula C32H60N8O7 Molecular Weight 668

509–514 (2020)

87 SMILES Cl

35 Purity (HPLC) >= 95% Solubility DMSO

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan fluorescent Ubiquitination and degradation of SUMO1SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by