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IP 3 -sensitive Ca 2+ stores can be activated by G protein-coupled receptors such as Group I metabotropic glutamate receptors (mGluRs) or muscarinic acetylcholine receptors, which activates phospholipase C (PLC), which in turn cleaves phosphatidylinositol biphosphate (PIP 2 ), causing the release of diacylglycerol (DAG) and IP 3

doi: 10.1016/j.tim.2017.06.004 76 RusuIGSuharoschiRVodnarDCPopCRSocaciSAVulturarRet al

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Relations between von Willebrand factor, markers of oxidative stress and microalbuminuria in patients with type 2 diabetes mellitus

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long-term use can cause significant adverse effects including kidney problems, hypertension, and non-melanoma skin cancers (Paul 2003