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With central neural blockade these changes may be attributable to block of autonomic fibers, a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system

Pinch the skin, insert the needle at a 45 to 90 degree angle (depending on body composition), inject slowly, hold for 5 to 10 seconds, withdraw

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Anti-CD47 therapy alone has shown efficacy against MM (64, 68), and its therapeutic impact is improved when combined with CD38-targeting agents

No serious adverse events reported in preclinical

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