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Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion

Abstract Accumulating evidence suggests that glutathione loss is closely associated with the progression of neurodegenerative disorders

Glutathione also plays critical roles in plant disease resistance, cell proliferation, root development, salt tolerance, and protection against chilling damage (Vernoux et al., 2000

Wiedermann et al., 1986) is devastating to the delicate tissue of the inner ear, and immunization against these pathogens provides significant protection (Schuchat et al., 1997)