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8 Clinical application prospects of DPP1 inhibitors 8.1 Bronchiectasis Bronchiectasis represents a chronic respiratory disease characterized by permanent and abnormal bronchial dilation, usually secondary to recurrent airway infections and inflammation ( Current clinical practice lacks specific therapies approved for treating bronchiectasis, with clinical management primarily relying on empirical treatment strategies including antibiotic use, airway secretion clearance techniques, and bronchodilator application

Tran TT, Ahn J, Reau NS

TB-500: Modulates actin polymerization, enhances cellular motility, supports angiogenesis, and reduces inflammation through the regulation of cytokine production and promotion of anti-inflammatory macrophage polarization

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This results in chronic hypercortisolism, adrenocortical hyperplasia, glucose intolerance and mature-onset obesity, resembling human Cushings syndrome 64