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Only atomic coordinates were refined

Apr 2020;11(2):327-340

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Pharmacokinetic Interaction: CYP3A4 and P-Glycoprotein Inhibition Berberine inhibits cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) in vitro and in vivo

If only "glutathione" is mentioned, and the GMP receives variants like the L-form, reduced, or S-Acetyl, then the GMP would halt the manufacturing process