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DOI: 10.1038/s41467-026-68825-2,

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Essentially, children born of women who smoked while pregnant are compelled to smoke excessively themselves because they derive much less pleasure from the nicotine dose in a typical cigarette and must compensate by inhaling a greater amount of nicotine

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Direct lung inhales (DL) typically result in larger vapor volume and higher nicotine intake compared to mouth-to-lung (MTL) inhales