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Some of the more commonly reported include: Joint and Muscle Related Symptoms Joint hypermobility Joint and muscle pain Frequent sprains Dislocations Spinal curve changes such as scoliosis or kyphosis Skin Related Symptoms Soft velvety-like skin Skin hyperextensibility Fragile skin that tears or bruises easily Slow wound healing Some people with EDS may also experience cardiovascular issues such as arterial fragility, gastrointestinal issues, or bowel/bladder problems

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We excluded patients with DM, alcohol use, or hepatitis B/C

Rapid Liquid ChromatographyTandem Mass Spectrometry Analysis of Two Urinary Oxidative Stress Biomarkers: 8-oxodG and 8-isoprostane

We hypothesize that this limited effect may also be attributable to a narrow dosing window within which a p53-specific effect may be observed

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