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Combined with MEK inhibitors, it concurrently suppresses MAPK signaling and reverses epigenetic silencing, yielding synergistic antitumor effects in breast cancer and melanoma [101,102,103]

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Although citicoline is included in TBI therapeutic regimen in 59 countries, only one multicenter, randomized, double-blind, placebo-controlled trial has been conducted in the US

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De Rosa MC, Sanna MT, Messana I et al (1998) Glycated human hemoglobin (HbA1c): functional characteristics and molecular modeling studies